Determination of Optimum Values of Descriptors to Set Filters for Synthetic Tri-Pyrrole Derivatives (Prodiginines) Against Multi Drug Resistant Strain of Plasmodium Falciparum
نویسندگان
چکیده
Department of Chemistry, Vidya Bharati College, Camp, Amravati, Maharashtra, India Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran Laboratoire Chimie des Matériaux, Université Mohammed Premier, Oujda-60000, Morocco Creighton University, Omaha, NE, USA Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India Department of Pharmaceutical Chemistry, Kind Saud University, Alkharj, Saudi Arabia
منابع مشابه
The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method
Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...
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Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...
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The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
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Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world. The conventional antiparasitic chemotherapy still suffers from side effects and drug resistance. Therefore, the development of novel antimalarial and leishmanicidal drugs rem...
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Background: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern of the developing countries.This resistance has prompted a re-examination of the pharmacology of alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is a 4-aminoquinoline antimalarial which is effective against many chloroquine-resistant strains o...
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